Ultrasonic Spraying Equipment Is Used For Atomized Spraying Of Bio-protein Coating Solutions.
Nov 18, 2025
Ultrasonic spraying equipment, with its core advantages of low-damage atomization and high-precision deposition, solves the pain points of bio-protein denaturation and difficulty in controlling coating uniformity in atomized spraying of bio-protein coating solutions. It is currently widely used in biomedical fields such as medical implants and biosensors. Targeted optimization solutions are available for process parameters and equipment compatibility. The following is a detailed introduction: Core Application Scenarios
Implantable Medical Device Coating: This is the core application area of this equipment. In orthopedics, collagen coating solutions can be sprayed onto the surface of titanium alloy artificial joints, activating osteoblast adhesion and proliferation, significantly shortening bone integration time, and reducing the incidence of postoperative loosening. In the cardiovascular field, coating solutions such as fibrinogen onto coronary artery stents can inhibit platelet aggregation and significantly reduce the risk of in-stent thrombosis. In addition, it can also be used for protein coating spraying of drug-eluting balloons, improving the biocompatibility between the balloon and vascular tissue.
Coatings for Biodiagnostic Equipment: On in vitro diagnostic devices such as biosensors and microfluidic chips, coatings containing albumin, enzymes, and other biological proteins can be sprayed. These coatings enhance the biospecific recognition capabilities of the sensors, ensuring the accuracy of diagnostic results. This equipment can also be used to coat in vitro diagnostic consumables, such as coating specific proteins onto the surface of certain detection chips to enhance detection sensitivity.
Coatings for Other Medical Consumables: For some special medical textiles, such as antibacterial bandages, spraying a coating containing antibacterial proteins can impart antibacterial properties. Additionally, spraying specific protein coatings onto the inner walls of certain special syringes can reduce tissue irritation during injection and improve safety.
Key Process Parameters for Adaptation to Ultrasonic Spraying Equipment: Precise parameter control is necessary to balance the activity of the biological protein with the coating quality. Different protein characteristics require different parameter combinations:
Atomization Frequency: This needs to be adjusted according to the protein's molecular weight. Small molecule proteins, such as insulin, are suitable for high-frequency atomization of 80-100kHz; large molecule proteins, such as albumin, are suitable for low-frequency atomization of 20-40kHz to reduce the damage to the protein's spatial structure caused by high-frequency vibration.
Liquid supply and movement parameters: Taking the deposition of a 100nm thick collagen coating as an example, controlling the liquid supply flow rate at 0.3mL/min and setting the spraying movement speed to 2mm/s achieves a uniform coating free of pinholes and cracks. Simultaneously, a closed-loop control system allows for stepless adjustment of the coating thickness from 50 to 500nm.
Environmental conditions: The spraying environment needs to be maintained at a temperature of 20-25℃ and a relative humidity of 40%-60% to prevent excessively rapid droplet evaporation that could lead to coating cracking, and to prevent high temperature and humidity from damaging protein activity.
Significant technical advantages:
High activity retention rate: The atomization process does not require high-pressure airflow, resulting in uniform energy distribution and a protein spatial structure destruction rate of less than 5%, far superior to traditional pneumatic spraying, maximizing the preservation of the biological activity of the protein.
High material utilization and low loss: Minimal overspray during spraying, with a liquid utilization rate exceeding 95%, not only reduces the loss of expensive biological protein raw materials but also lowers costs. Furthermore, the nozzle has a self-cleaning function, making it less prone to clogging. This reduces maintenance costs and avoids material waste and coating defects caused by nozzle blockage.
Adapting to Personalized Needs: The equipment can flexibly adjust the spraying range and coating thickness, enabling customized protein coating preparation for different patients' implantable device sizes and diagnostic equipment testing needs. For example, the protein coating range of the stent can be adjusted according to the blood vessel diameter to adapt to the clinical needs of different patients.
What are the advantages of ultrasonic spraying equipment in the atomization spraying of biological protein coating liquids?
The core advantages of ultrasonic spraying equipment in the atomization spraying of biological protein coating liquids are low damage while preserving activity, high utilization rate and cost reduction, and high precision adaptation to needs. Specifically, this can be divided into three points:
1. Maximizing the Preservation of Biological Protein Activity: The atomization process does not require high-pressure airflow, and the energy distribution is uniform, with a damage rate to the protein's spatial structure of less than 5%. Compared to the high-pressure impact of traditional pneumatic spraying, it avoids protein denaturation and inactivation, ensuring that the coating's biological functions (such as antibacterial properties and cell adhesion promotion) are not affected.
2. High Material Utilization + Low Maintenance Costs: Extremely low overspray volume results in a bio-protein raw material utilization rate exceeding 95%, significantly reducing the waste of expensive protein materials. The nozzle has a self-cleaning function, preventing clogging due to protein deposits, reducing equipment maintenance frequency and costs, and avoiding coating defects caused by clogging.
3. High Precision + Strong Adaptability: Precise control of coating thickness (steplessly adjustable from 50-500nm) and flexible adjustment of spraying range and uniformity. It is compatible with substrates of different sizes, such as implantable devices and biosensors, and can also meet personalized clinical needs (such as customized stent coating ranges). The coating is free of pinholes and cracks, exhibiting high quality stability.